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The efficacy of Vedolizumab ( Entyvio ), an alpha4beta7 integrin antibody, in Crohn's disease is unknown.In an integrated study with separate induction and maintenance trials, researchers have assesse ...


Takeda Pharmaceutical has announced top-line results from the international, randomized, placebo-controlled, double-blind GEMINI II pivotal phase 3 trial. The trial has evaluated Vedolizumab in 1,11 ...


The alpha4beta7 integrin monoclonal antibody Vedolizumab ( Entyvio ) is hypothesised to be gut selective. Effects of Vedolizumab on immune responses to parenterally or enterally administered antigens ...


Vedolizumab ( Entyvio ) is a humanized monoclonal antibody that inhibits adhesion and migration of leukocytes into the gastrointestinal tract by preventing the alpha4beta7 integrin subunit from bindin ...


Crohn’s disease and ulcerative colitis are chronic, relapsing inflammatory disorders of the gastrointestinal ( GI ) tract. In both Crohn’s disease and ulcerative colitis, leukocytic infiltration of th ...


Vedolizumab ( Entyvio ) is a humanized version of Act-1, a murine antibody originally developed in the 1980s with activity against the alpha4beta7-integrin heterodimer. During leukocyte extravasation ...


Vedolizumab ( Entyvio ) is a gut-selective antibody to alpha4beta7 integrin for the treatment of ulcerative colitis and Crohn's disease. An integrated summary of the safety of Vedolizumab was reported ...