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Favourable efficacy and safety profiles for Simeprevir ( Olysio ) in combination with Pegylated interferon alpha ( PEG-IFN alpha ) and Ribavirin ( triple therapy ) have been shown in clinical trials. ...


Infliximab ( Remicade ) has been shown to have beneficial effects on bone metabolism in patients with Crohn's disease ( CD ) although as yet the exact mechanisms have not been fully elucidated. A s ...


Endoscopic healing and clinical remission are important parameters to evaluate therapeutic efficacy in Crohn's disease. The aim of a study was to investigate the clinical effectiveness of Adalimumab ...


Data about the effectiveness of biologics, including anti-tumor necrosis factor ( anti-TNF ) therapy and anti-integrin strategies, in antibiotic refractory pouchitis or Crohn's disease-associated pouc ...


The objective of the present study was to evaluate the effectiveness and safety of Adalimumab ( Humira ) in children with Crohn disease ( CD ) who experienced Infliximab ( Remicade ) failure at the po ...


TNF inhibitors are effective in the treatment of ulcerative colitis. Adalimumab ( Humira ), a fully human TNF inhibitor, is increasingly used both as primary anti-TNF agent and in patients switching f ...


The efficacy of Adalimumab ( Humira ) in children with moderately to severely active Crohn’s disease enrolled in the IMAgINE 1 trial has been reported up to week ( wk ) 52. Long-term efficacy of Adali ...


The FDA ( Food and Drug Administration ) has approved Ramucirumab ( Cyramza ) in combination with Paclitaxel as a treatment for people with advanced or metastatic gastric or gastroesophageal junction ...


Crohn’s disease-related inflammation is characterized by defective activity of the immunosuppressive cytokine transforming growth factor ( TGF )-beta1, due to high Smad7, an inhibitor of TGF-beta1, si ...


TOUCHSTONE, the phase 2 trial of RPC1063 in ulcerative colitis ( UC ), met its primary endpoint and all secondary endpoints with statistical significance in patients on the 1 mg dose of RPC1063 in the ...


Adalimumab ( Humira ) is the key treatment for ulcerative colitis unresponsive or intolerant to standard treatments. The aim of the study was to assess the efficacy and safety of Adalimumab in treatin ...


RPC1063 is an orally available, potent, selective sphingosine-1-phosphate 1 receptor ( S1P1R ) agonist, which has been shown to decrease inflammation in animal models of colitis. Stimulation of S1P1 ...


The objective of a study was to evaluate the impact of a diet and physical activity intervention ( BeWEL ) on weight change in people with a body mass index greater than 25 weight (kg) / height (m)2 a ...


Compared with open resection, laparoscopic resection of rectal cancers is associated with improved short-term outcomes, but high-level evidence showing similar long-term outcomes is scarce. The tria ...


Adalimumab ( Humira ) is effective for induction and maintenance of remission in patients with moderate to severe ulcerative colitis. Researchers have assessed whether Adalimumab, in addition to sta ...


Diverticulitis is a common disease. Recent changes in understanding its natural history have substantially modified treatment paradigms. It has been reviewed the etiology and natural history of div ...


The safety and efficacy of Adalimumab ( Humira ) for patients with moderately to severely active ulcerative colitis has been reported up to week 52 from the placebo-controlled trials ULTRA ( Ulcerativ ...


Postoperative pancreatic fistula is a major contributor to complications and death associated with pancreatic resection. Pasireotide ( Signifor ), a somatostatin analogue that has a longer half-life t ...


Tofacitinib ( Xeljanz ), an orally administered Janus kinase inhibitor, blocks signaling through gamma-chain-containing cytokines ( interleukins 2, 4, 7, 9, 15, and 21 ). Researchers have performed ...


Eli Lilly has announced that the FDA ( Food and Drug Administration ) has approved Cyramza ( Ramucirumab ) as a single-agent treatment for patients with advanced or metastatic gastric cancer or gastro ...


The alpha4beta7 integrin monoclonal antibody Vedolizumab ( Entyvio ) is hypothesised to be gut selective. Effects of Vedolizumab on immune responses to parenterally or enterally administered antigens ...


The objective of a study was to compare high-definition white-light endoscopy ( HDWLE ) alone with random biopsy ( RB ) and HDWLE plus eCLE ( endoscope-based confocal laser endomicroscopy system ) and ...


Metastatic colorectal cancer ( mCRC ) is commonly treated with 5-Fluorouracil, Folinic acid, and Oxaliplatin or Irinotecan. The multitargeted kinase inhibitor, Regorafenib ( Stivarga ), was combined ...


Information on efficacy and predictors of response to Adalimumab ( Humira ) in ulcerative colitis clinical practice is limited. The aim of study was assessed the response to Adalimumab and its pred ...


Optimizing anti-tumor necrosis factor therapy is often required in patients with Crohn's disease. In case of partial response or loss of response to Adalimumab ( Humira ) 40 mg every other week, the i ...


Vedolizumab ( Entyvio ) is a humanized monoclonal antibody that inhibits adhesion and migration of leukocytes into the gastrointestinal tract by preventing the alpha4beta7 integrin subunit from bindin ...


A new generation of oral anticoagulants ( nOAC ), which includes thrombin and factor Xa inhibitors, has been shown to be effective, but little is known about whether these drugs increase patients' ris ...


In the past decades, prophylactic colectomy to prevent development of colorectal cancer substantially has improved prognosis in patients with familial adenomatous polyposis ( FAP ). The mortality patt ...


A phase III clinical trial of the drug Abraxane ( nanoparticle albumin-bound Paclitaxel; Nab-Paclitaxel ) in combination with current standard of care Gemcitabine ( Gemzar ) in patients with advanced ...


Travellers' diarrhoea causes substantial acute and long-term morbidity. Chemoprophylaxis with fluoroquinolones or Rifaximin ( Normix, Xifaxan ) is effective in prevention of diarrhoea in individuals t ...


A systematic review and meta-analysis of data from randomized controlled trials ( RCTs ) to evaluate the efficacy and safety of Certolizumab pegol ( Cimzia ) was performed. A total of five RCTs, in ...


Whether sequential treatment can replace triple therapy as the standard treatment for Helicobacter pylori infection is unknown.The efficacy of sequential treatment for 10 days and 14 days with triple ...


The efficacy of Vedolizumab ( Entyvio ), an alpha4beta7 integrin antibody, in Crohn's disease is unknown.In an integrated study with separate induction and maintenance trials, researchers have assesse ...


The hemoglobin threshold for transfusion of red cells in patients with acute gastrointestinal bleeding is controversial. Researchers have compared the efficacy and safety of a restrictive transfusion ...


Results of the phase II, randomized, double-blind, placebo-controlled RECAP trial of Ruxolitinib ( Jakafi ), its oral JAK1 and JAK2 inhibitor, in combination with Capecitabine ( Xeloda ) in patients w ...


Bayer HealthCare has announced that the European Commission has approved Stivarga ( Regorafenib ) tablets for the treatment of adult patients with metastatic colorectal cancer ( mCRC ) who have previo ...


Aspirin ( Acetylsalicylic acid ) is known to lower risk for some cancers, and a new study led by a UC San Francisco researcher, Carlo Maley, points to a possible explanation, with the discovery that A ...


Final data from IMPACT study provide proof of principle for new treatment approach. The findings confirm the biological action of the drug called MGN1703 and suggest it may be possible to identify whi ...


There are no agents specifically approved in the United States or European Union for advanced gastric cancer patients. Gastric cancer is the fourth most common cancer in the world and the second-leadi ...


PAVES ( Pegfilgrastim and Anti-VEGF Evaluation Study ) trial has evaluated Pegfilgrastim ( Neulasta ) in 845 patients receiving FOLFOX or FOLFIRI and Bevacizumab ( Avastin ) for the first-line treatme ...


The chance of ending up in a nursing facility appears to be significantly lower for older patients who undergo a laparoscopic procedure than for those who have open surgical resection for colon cancer ...


In an analysis of the results of interventions to eradicate the bacterium Helicobacter pylori ( a risk factor for gastric cancer ) in seven diverse community populations in Latin America, researchers ...


Numerous epidemiologic studies have shown that a diet high in salt is associated with an increased risk of gastric cancer. Timothy L. Cover and colleagues of Vanderbilt University have shown that high ...


In two large studies, the association between Acetylsalicylic acid ( Aspirin ) use and risk of colorectal cancer was affected by mutation of the gene BRAF, with regular Aspirin use associated with a l ...


Stem cells taken from amniotic fluid were used to restore gut structure and function following intestinal damage in rodents, in new research published in the journal Gut. The findings pave the way for ...


Intestinal bacteria may have a greater influence on us than was previously thought. In a study published in the Nature, researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden and Cha ...


A subset of colorectal cancers responds to anti-epidermal growth factor receptor ( anti-EGFR ) therapies, but develops resistance within months. Among cancers that develop resistance to anti-EGFR ther ...


Researchers from UCLA's Jonsson Comprehensive Cancer Center have discovered that specific types of bacteria that live in the gut are major contributors to lymphoma. Published in the journal Cancer Re ...


The human papillomavirus ( HPV ) triples the risk of people developing yet another cancer, oesophageal squamous cell carcinoma ( OSCC ), according to research led by University of New South Wales ( UN ...


The association between fibromyalgia and autoimmune diseases has been widely reported in literature. Coeliac disease is a small intestine immune-mediated disorder triggered by gluten ingestion in gene ...



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